Author Ryan, Calen P
Article Title Androgen receptor polyglutamine repeat length (AR-CAGn) modulates the effect of testosterone on androgen-associated somatic traits in Filipino young adult men
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Source American journal of physical anthropology. vol. 163, no. 2 (Jun. 2017), p. 317-327
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Call number Article
Journal Title American journal of physical anthropology.
Copy vol. 163, no. 2 (Jun. 2017), p. 317-327
ISSN 00029483
Co author McDade, Thomas W
Co author Georgiev, Alexander V
Co author Gettler, Lee T
Co author Kuzawa, Christopher W
Co author Eisenberg, Dan T.A
Co author Rzhetskaya, Margarita
Co author Agustin, Sonny S
Co author Hayes, M. Geoffrey
Brief substance The androgen receptor (AR) mediates expression of androgen-associated somatic traits such as muscle mass and strength. Within the human AR is a highly variable glutamine short-tandem repeat (AR-CAGn), and CAG repeat number has been inversely correlated to AR transcriptional activity in vitro. However, evidence for an attenuating effect of long AR-CAGn on androgen-associated somatic traits has been inconsistent in human populations. One possible explanation for this lack of consistency is that the effect of AR-CAGn on AR bioactivity in target tissues likely varies in relation to circulating androgen levels
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